Heartgard Plus for Dogs

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Rating: 4.6/5
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Starting at Only: $36.37

Heartgard Plus Chewables Small Dogs up to 25lbs (Blue)

Pack Size
Qty
Price
6 Doses
$36.37
12 Doses
$69.01

Nuheart Generic Heartgard for Small Dogs upto 25lbs (Blue)

Pack Size
Qty
Price
6 Tablet
$23.89
12 Tablet
$40.21

Heartgard Plus Chewables for Medium Dogs 26-50lbs (Green)

Pack Size
Qty
Price
6 Doses
$40.21
12 Doses (Exp. May 2027)
$76.69

Nuheart Generic Heartgard for Medium Dogs 26-50lbs (Green)

Pack Size
Qty
Price
6 Tablet
$24.85
12 Tablet
$45.01

Heartgard Plus Chewables for Large Dog 51-100lbs (Brown)

Pack Size
Qty
Price
6 Doses
$47.89
12 Doses
$92.05

Nuheart Generic Heartgard for Large Dogs 51-100lbs (Red)

Pack Size
Qty
Price
6 Tablet
$25.81
12 Tablet
$48.85

Heartgard Plus for Dogs: Monthly Heartworm Prevention Chewables

Heartgard Plus is a convenient and tasty way to safeguard your dog from heartworm disease. The threat of heartworm infections is prevalent in all 50 states, and that is why your vet would suggest you use a heartworm preventive for your dog all year round, no matter the part of the country you live in.

This real-beef chew comes in handy as it is widely accepted by dogs and helps protect them from heartworms and internal parasites for one month. This vet-recommended chewable is suitable for dogs and puppies from 6 weeks of age, and is available in weight-specific doses for dogs of different sizes.

Why choose Heartgard Plus Chewables?

When administered as recommended, this monthly chewable:

  • Prevents canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis)
  • Treats and controls 2 species of roundworms and 3 species of hookworms

Heartgard Plus: Vet-approved heartworm prevention chewable

Heartgard Plus contains two active ingredients: Ivermectin and pyrantel. Ivermectin allows the immune system to recognize and inactivate heartworm larvae before they can develop into adults, and helps prevent heartworm disease. Pyrantel works on the internal parasites, as it treats and controls hookworms and roundworms.

Ingredients

Heartgard Plus: Ivermectin, Pyrantel

Nuheart: Ivermectin

Why To Use Heartgard Plus
  • Vet-recommended oral heartworm preventive
  • Easily acceptable, real-beef chew
  • One dose offers month-long protection
  • Treats & controls hookworms and roundworms
  • Can be given to dogs from 6 weeks of age
  • Available in weight-specific doses for dogs of different sizes
Usage Directions For Heartgard Plus
  • Heartgard Plus for dogs is available in three different packs for weight-specific dosage. The packs are color-coded for easy identification and convenient selection.
  • Check your dog’s weight and select the pack that is appropriate for their body weight.
  • Remove one chewable from the foil-backed blister card.
  • Offer the chew to your dog by hand. Administer it in a way that encourages your dog to chew and not swallow it without chewing.
  • If your dog has a habit of swallowing treats, you may break this chew into pieces and feed it to avoid swallowing.
  • Alternatively, you may add the intact chew to a small amount of your dog’s food to encourage chewing.
  • Ensure that your dog consumes the complete dose at one time.
  • Observe your dog for several minutes after administering the dosage to ensure that any part of the dose is not lost or rejected.
  • If you suspect that any of the dose has been lost, re-dosing is recommended.
  • For optimal results, give Heartgard Plus Chewable to your dog once a month on or about the same day of the month.
  • If you are replacing another heartworm preventive, it is required to give the first dose of Heartgard Plus within a month (30 days) of the last dose of the former preventive.

Dosage:

Dog Weight Pack Color Ivermectin Content Pyrantel Content Chewables Per Month
0 to 25 lbs Blue 68 mcg 57 mg 1
26 to 50 lbs Green 136 mcg 114 mg 1
51 to 100 lbs Brown 272 mcg 227 mg 1

*For dogs over 100 lbs.: Use the appropriate combination of these chewables.

Heartgard Plus Protective Measures

For animals:

  • This chew is for oral use in dogs only.
  • Do not use it in puppies less than 6 weeks of age.
  • Read the entire label and follow the directions for use.

For humans:

  • Not intended for use in humans.
  • Keep out of reach of children.
  • In case of accidental ingestion, contact a physician immediately.

Precautions:

  • Heartgard Plus is not effective against adult D. immitis. Dogs should be tested for existing heartworm infection, and infected dogs must be treated to remove adult heartworms and microfilariae before starting the prevention program with this chewable.

Storage & Disposal:

  • Keep this product in a secure location, out of reach of dogs, cats and other animals to prevent accidental ingestion or overdose.
  • Store between 68°F - 77°F (20° - 25°C). Excursions between 59°F - 86°F (15° - 30°C) are permitted.
  • Store in the original packaging until use to protect from light.

Can I give Heartgard Plus to my pregnant dog?

In studies conducted by the manufacturer, Heartgard Plus has shown a wide margin of safety in pregnant and breeding female dogs when administered at recommended levels. Consult your veterinarian for further guidance.

Can I use Heartgard Plus with other medications?

In clinical trials by the manufacturer, commonly used flea collars, dips, shampoos, anthelmintics, antibiotics, vaccines and steroid preparations have been used along with Heartgard Plus.

Do I have to get my dog tested for heartworms before using Heartgard Plus?

Yes. Heartgard Plus is not effective against adult D. immitis. Dogs should be tested for existing heartworm infection, and infected dogs must be treated to remove adult heartworms and microfilariae before starting the prevention program with Heartgard Plus.

How do dogs get heartworms?

Dogs get infected with heartworms due to a bite from an infected mosquito. Heartworm larvae are deposited on the skin due to the mosquito bite. When the mosquito leaves, the heartworm larvae enter the dog’s body through the bite wound.

When should I start giving Heartgard Plus to my dog?

The initial dose of Heartgard Plus should be given within a month (30 days) after the dog’s first exposure to mosquitoes.

How should I shift to Heartgard Plus from another heartworm preventive?

When replacing another heartworm preventive, the first dose of Heartgard Plus must be given within a month (30 days) of the last dose of the former preventive for your dog’s uninterrupted protection.

What if I miss a dose of Heartgard Plus?

Heartgard Plus must be given once a month on or about the same day of the month. If a dose is delayed, give Heartgard Plus immediately and resume the recommended dosing regimen to minimize the opportunity for the development of adult heartworms.

Where can I buy Heartgard Plus chews?

You may buy Heartgard Plus heartworm prevention chews from online stores, like PetCareClub. Our pet care products-specific store carries a variety of pet essentials at competitive prices and offers hassle-free order deliveries.

Disclaimer: The product information displayed here is sourced from the official label and documentation available with the manufacturer and does not intend to replace veterinary advice.

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Heartgard Plus: A real guard against heartworm disease

A real-beef chew to prevent canine heartworm disease, as well as treat and control 3 species of hookworms and 2 species of roundworms in dogs. Recommended to be administered once a month, all year round.

Why Heartgard Plus?
Dog-preferred
#1 Dog-preferred chew

Delicious real-beef taste to make the monthly dosing easy and enjoyable

Vet-recommended
Vet-recommended heartworm preventive

A heartworm disease preventive with more than 30 years of proven protection and is recommended by veterinarians.

monthly dosage
Monthly dosage, year round protection

When given once every 30 days, Heartgard Plus helps prevent heartworm disease in dogs all year long

Protects puppies
Protects puppies too

With no minimum weight requirement, Heartgard Plus offers heartworm disease prevention for puppies as young as 6 weeks of age.

Treats & controls
Treats & controls hookworms & roundworms

Heartgard Plus treats and controls 3 species of hookworms (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense) and 2 species of roundworms (Toxocara canis, Toxascaris leonina).

powerful ingredients
Powerful ingredients

Heartgard Plus contains two powerful ingredients: ivermectin and pyrantel.

Packs for dogs
Packs for dogs of all sizes

Available in 3 different sizes: for dogs up to 25 lbs, weighing between 26-50 lbs, & weighing between 51 100 lbs.

Is heartworm disease prevention necessary?

Heartworm disease is a potentially deadly disease that can cause permanent damage to dogs’ health even before it can be diagnosed. When an infected mosquito bites a dog, they get exposed to the risk of heartworm disease. If neglected and left untreated, it can lead to heart failure and eventually death of the infected dog. The treatment of heartworm disease is complicated and expensive. Compared to this, heartworm disease prevention is simple. Heartgard Plus is one such convenient option to prevent heartworm disease and treat and control 5 species of intestinal worms.

Do all dogs need heartworm disease prevention?

Heartworm disease cases have been reported in all the 50 states of the US in both indoor and outdoor pets. Also, a dog of any age can get infected with heartworm disease. Heartgard Plus chews attack heartworm larvae that have infected dogs in the previous 30 days, which prevents larvae from growing into adult heartworms and causing harm.

heartworm-disease
How do dogs get infected with heartworms?

It all starts with a mosquito bite.

infact infact
  1. A mosquito bites a heartworm-infected animal and ingests heartworm larvae.
  2. The heartworm larvae develop to the infective larvae stage inside the mosquito.
  3. The mosquito bites a dog.
  4. The heartworm larvae enter the tissue of the new host, reach adult & mature adult stages in the bloodstream. Treatment is necessary at this stage.

Heartgard Plus for Dog Reviews

4.6

242 Reviews(s)

5 Star
61.98 %
4 Star
37.6 %
3 Star
0.41 %
2 Star
0 %
1 Star
0 %

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Food Bowl
Submitted by Holden on Sep 08, 2026
Giving this around mealtime makes it a natural part of my dog's day.
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Steady Protection
Submitted by Zavier on Sep 02, 2026
This fits naturally into my dog's regular wellness routine without adding much effort.
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Monthly Habit
Submitted by Fletcher on Aug 25, 2026
Giving this on schedule has become a simple part of my dog's monthly care.
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Monthly Habit
Submitted by Zayne on Aug 18, 2026
It has become an easy part of my dog's regular monthly care.
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Simple Routine
Submitted by Kade on Aug 11, 2026
Giving this as part of my dog's regular schedule has been straightforward
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