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Frontline Plus vs. Selehold (Generic Revolution) for Cats: A Detailed Comparison

calendar  Jun 13, 2025

frontline-plus-vs-selehold-generic-revolution-for-cats-a-detailed-comparison

Choosing an appropriate parasite treatment for your cat can be a tiring task, considering the wide range of products available on the market. It gets all the more challenging when you have to choose between two popular options. Frontline Plus for Cats and Selehold for Cats are one such pair of treatments that often land cat parents in confusion.

In this blog, we’re featuring a detailed comparison between the two products to help you make a suitable choice for your feline buddy. Read on to find out more.

Frontline Plus vs. Selehold Spot-on Solution for Cats – An Overview

Frontline Plus

Frontline Plus for Cats kills fleas, flea eggs and larvae, chewing lice and ticks. It prevents all flea life stages from developing, stops existing infestations and prevents the establishment of new ones. The treatment kills all life stages of ticks in species like brown dog ticks, American dog ticks, lone star ticks and deer ticks. It also kills ticks that may transmit Lyme disease, haemobartonellosis, ehrlichiosis, babesiosis, anaplasmosis and other tick-borne diseases. It can be used on cats and kittens from 8 weeks of age and 1.5 lbs of body weight.

Selehold Spot-on Solution

Selehold Spot-on Solution for Cats is indicated for the treatment and prevention of flea infestations, treatment of ear mites, biting lice infestations, adult roundworms and intestinal hookworms. It also helps prevent heartworm disease caused by Dirofilaria immitis when administered monthly. The treatment is suitable for cats and kittens from 6 weeks of age.

Frontline Plus & Selehold Spot-on Solution – Similarities and Differences

Here are the key similarities and differences between Frontline Plus and Selehold Spot-on Solution.

Similarities:

  • Frontline Plus and Selehold Spot-on are topical treatments.
  • Each of them treats fleas and prevents flea infestations.
  • Both treatments can be safely used on pregnant and lactating queens.
  • A single dose of Frontline Plus and Selehold Spot-on protects cats for one month.

Differences:

  • Frontline Plus kills multiple species of ticks. However, Selehold for Cats doesn’t offer coverage against this parasite.
  • While Frontline Plus eliminates chewing lice, Selehold Spot-on treats biting lice infestations.
  • Frontline Plus doesn’t treat intestinal worms. Selehold Spot-on treats intestinal worms, such as roundworms and hookworms.
  • Frontline Plus doesn’t help prevent heartworm disease, Selehold Spot-on, on the other hand, prevents heartworm disease caused by Dirofilaria immitis.
  • While Frontline Plus is composed of fipronil and (S)-methoprene as its active ingredients, Selehold Spot-on contains Selamectin.
  • Frontline Plus is suitable for cats and kittens from 8 weeks of age, weighing at least 1.5 lbs of body weight. Selehold Spot-on is formulated for felines from 6 weeks.

A Detailed Comparison

The following table features a detailed comparison of the product features of Frontline Plus and Selehold Spot-on:

Bottom Line:

Both Frontline Plus Flea and Tick Treatments for Cats and Selehold Spot-on are vet-recommended topical parasitic treatments that protect cats and kittens against a range of parasites. However, they differ in compositions, parasite coverage and age and weight criteria.

If you want to protect your feline against fleas, you can use either of the treatments. But if you’re looking for coverage against chewing lice and tick infestations caused by American dog ticks, deer ticks, brown dog ticks and lone star ticks you should go for Frontline Plus. Also, if you want to treat roundworms, hookworms, biting lice and ear mites or prevent heartworm disease, you should opt for Selehold. However, do ensure that your feline buddy meets the minimum age and weight requirement mentioned in the treatments’ product labels.

You can purchase both Frontline Plus and Selehold Spot-on at the best prices from PetCareClub. Check out our online store today to get your hands on attractive deals on a wide range of pet essentials and treatments from the comfort of your home.